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Article

Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail.

Developmental biology - 15 Nov 2003

Lin Meei-Hua, Kopan Raphael

Abstract excerpt

Using an antibody directed against gamma-secretase-generated antigen unique to activated Notch1, we mapped Notch1 activation strictly to suprabasal cells in epidermis, nail matrix, and other skin appendages during normal development. The consequences of Notch1 activation in keratinizing nail cells were investigated in a transgenic mouse model. Ectopic activation of Notch1 in postmitotic cells within the nail...

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Identifiers

PMID: 14597207
DOI: 10.1016/j.ydbio.2003.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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