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Article

Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.

The Journal of investigative dermatology - 1 Jan 2015

Rorke Ellen A, Adhikary Gautam, Young Christina A, Roop Dennis R, Eckert Richard L

Abstract excerpt

Keratodermas comprise a heterogeneous group of highly debilitating and painful disorders characterized by thickening of the skin with marked hyperkeratosis. Some of these diseases are caused by genetic mutation, whereas other forms are acquired in response to environmental factors. Our understanding of signaling changes that underlie these diseases is limited. In the present study, we describe a keratoderma...

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Share to Abnormalities, Multiple
Share to Constriction, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Hand Deformities, Congenital

Share to Hearing Loss, Sensorineural

Share to Keratoderma, Palmoplantar

Share to Mice, Mutant Strains

Share to Transcription Factor AP-1

Source

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Identifiers

PMID: 25050598
DOI: 10.1038/jid.2014.310
PMCID: PMC4268309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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