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Article

β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche.

Science (New York, N.Y.) - 21 Mar 2014

Deschene Elizabeth R, Myung Peggy, Rompolas Panteleimon, Zito Giovanni, Sun Thomas Yang, Taketo Makoto M, Saotome Ichiko, Greco Valentina

Abstract excerpt

Wnt/β-catenin signaling is critical for tissue regeneration. However, it is unclear how β-catenin controls stem cell behaviors to coordinate organized growth. Using live imaging, we show that activation of β-catenin specifically within mouse hair follicle stem cells generates new hair growth through oriented cell divisions and cellular displacement. β-Catenin activation is sufficient to induce hair growth...

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Source

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Identifiers

PMID: 24653033
DOI: 10.1126/science.1248373
PMCID: PMC4096864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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