Article
Highly efficient transgene-independent recombination directed by a maternally derived SOX2CRE transgene.
Genesis (New York, N.Y. : 2000) - 1 Oct 2003
Vincent Stéphane D, Robertson Elizabeth J
Abstract excerpt
The Cre/loxP site-specific recombination system is a powerful tool that allows gene inactivation in a tissue- and time-specific manner. Several reports have shown that the Sox2Cre transgenic strain provides a very efficient means to delete gene function from the early epiblast (Hayashi et al.: Gene Expr Patterns 2:93-97, 2002; Vincent et al.: Genes Dev 17:1646-1662, 2003). Routinely, male studs carrying one null...
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