Article
The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects.
Human genetics - 1 Jan 2004
Brown Karen S, Kluijtmans Leo A J, Young Ian S, McNulty Helene, Mitchell Laura E, Yarnell John W G, Woodside Jayne V, Boreham Colin A, McMaster Dorothy, Murray Liam, Strain J J, Whitehead Alexander S
Abstract excerpt
Thymidylate synthase (TYMS) and 5,10-methylenetetrahydrofolate reductase (MTHFR) may compete for their common cofactor 5,10-methylenetetrahyhdrofolate (5,10-meTHF). Limiting 5,10-meTHF results in elevated homocysteine, especially in individuals homozygous for the T allele of the MTHFR C677T polymorphism. The TYMS gene has a tandem repeat polymorphism (two repeats or three repeats, designated 2R or 3R,...
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