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Article

Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects.

European journal of clinical pharmacology - 1 Jun 2009

Kodaira Chise, Sugimoto Mitsushige, Nishino Masafumi, Yamade Mihoko, Shirai Naohito, Uchida Shinya, Ikuma Mutsuhiro, Yamada Shizuo, Watanabe Hiroshi, Hishida Akira, Furuta Takahisa

Abstract excerpt

BACKGROUND AND AIMS: The effect of multidrug resistance transporter gene 1 (MDR1) on the bioavailability and kinetics of several substrates has not yet been fully elucidated. We evaluated the influence of MDR1 C3435T polymorphism on the pharmacokinetics and pharmacodynamics of lansoprazole in Japanese subjects. METHODS: Fifteen healthy volunteers with the rapid extensive metabolizer genotype of CYP2C19 were...

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PMID: 19238367
DOI: 10.1007/s00228-009-0625-8

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