Article
Nuclear receptors in disease: the oestrogen receptors.
Essays in biochemistry - 1 Jan 2004
Nilsson Maria, Dahlman-Wright Karin, Gustafsson Jan-Ake
Abstract excerpt
For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knockout (ERKO) mice...
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