Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C9 gene and susceptibility to major depressive disorder.

The pharmacogenomics journal - 1 Jan 2003

LLerena A, Berecz R, Dorado P, González A P, Peñas-LLedó E M, De La Rubia A

Abstract excerpt

Alteration of monoaminergic neurotransmission has been implicated in the pathophysiology of mood disorders, and CYP2C9 enzyme activity has been shown to be modulated by serotonin in vitro. The present study was aimed at analysing the frequency of CYP2C9 alleles (*1, *2, *3) among patients suffering from major depressive disorder. In all, 70 such suffering psychiatric outpatients were studied. The CYP2C9 genotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Depressive Disorder, Major

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Source

Identifiers

PMID: 14583800
DOI: 10.1038/sj.tpj.6500197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C9 gene and susceptibility to major depressive disorder.PMID 14583800Read ↗

The influence of CYP2C19*2 and CYP3A5*3 variants on the development of depression and effectiveness of therapy: A preliminary study.Semantic proximity Read ↗

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele.Semantic proximity Read ↗

[Association of SCN2A, ABCB1 and CYP2C19*3 with genetic susceptibility to major depressive disorder].Semantic proximity Read ↗

The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder.Semantic proximity Read ↗

Investigating CYP2C9*3 Polymorphisms in Patients with Neuropsychological Disorders through Pharmacogenomics TestingSemantic proximity Read ↗

CYP2C19-rs4986893 confers risk to major depressive disorder and bipolar disorder in the Han Chinese population whereas ABCB1-rs1045642 acts as a protective factor.Semantic proximity Read ↗

Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways.Semantic proximity Read ↗

Association between CYP19A1 rs6493497 and rs936306 polymorphisms and depression susceptibility in the Chinese population.Semantic proximity Read ↗

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.Semantic proximity Read ↗

Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors.Semantic proximity Read ↗

Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.Semantic proximity Read ↗

Investigation of CYP3A4*22 polymorphism effects on the depressed treatment by citalopram and sertralineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.