Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influence of CYP2C192 and CYP3A53 variants on the development of depression and effectiveness of therapy: A preliminary study.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2021

Świechowski Rafał, Jeleń Agnieszka, Pietrzak Jacek, Gałecki Piotr, Szmajda-Krygier Dagmara, Balcerczak Ewa

Abstract excerpt

The most common mental illness is depression; however, its pathogenesis is not fully understood. One of the factors that may influence its development and the effectiveness of therapy are the cytochromes of the p450 complex. CYP3A5 and CYP2C19 are involved in the metabolism of drugs used in the treatment of depression. These cytochromes can also generate reactive oxygen species, which are known to participate in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP3A

Share to Depression

Share to Gene Frequency

Share to Treatment Outcome

Share to Young Adult

Source

Identifiers

PMID: 34435592
DOI: 10.1016/j.biopha.2021.112055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

The influence of CYP2C19*2 and CYP3A5*3 variants on the development of depression and effectiveness of therapy: A preliminary study.PMID 34435592Read ↗

CYP2C9 gene and susceptibility to major depressive disorder.Semantic proximity Read ↗

A machine learning approach to predict treatment efficacy and adverse effects in major depression using CYP2C19 and clinical-environmental predictors.Semantic proximity Read ↗

Investigation of CYP3A4*22 polymorphism effects on the depressed treatment by citalopram and sertralineSemantic proximity Read ↗

Association between CYP19A1 rs6493497 and rs936306 polymorphisms and depression susceptibility in the Chinese population.Semantic proximity Read ↗

The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder.Semantic proximity Read ↗

Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients.Semantic proximity Read ↗

Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients.Semantic proximity Read ↗

No association between CYP2C19 genetic polymorphism with treatment remission to antidepressant venlafaxine in Han Chinese population.Semantic proximity Read ↗

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.