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Article

Alterations in the RB1 Pathway in Low‐grade Diffuse Gliomas Lacking Common Genetic Alterations

6 Apr 2011

Abstract excerpt

We recently reported that the vast majority (>90%) of low-grade diffuse gliomas (diffuse astrocytoma, oligoastrocytoma and oligodendroglioma) carry at least one of the following genetic alterations: IDH1/2 mutation, TP53 mutation or 1p/19q loss. Only 7% of cases were triple-negative (ie, lacking any of these alterations). In the present study, array comparative genomic hybridization (CGH) in 15 triple-negative...

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PMID: 21470325
DOI: 10.1111/j.1750-3639.2011.00492.x

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