Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.

doi:10.1007/s004010051107

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Article

Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.

Acta neuropathologica - 1 Nov 1999

Simon M, Köster G, Menon A G, Schramm J

Abstract excerpt

Homozygous chromosome 9p deletions in gliomas commonly include the CDKN2A and CDKN2B genes, which code for the structurally highly homologous cdk inhibitors/tumor suppressors p16 and p15, respectively. Alternative splicing of the CDKN2A gene results in the expression of p14(ARF). Interestingly, n...

Topics

Base Sequence
Brain Neoplasms
DNA, Neoplasm
Gene Silencing
Genes, p16
Glioma
Humans
Molecular Sequence Data
Mutation
Proteins
Tetracycline
Tumor Cells, Cultured
Tumor Suppressor Protein p14ARF

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