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Article

Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Famili Iman, Forster Jochen, Nielsen Jens, Palsson Bernhard O

Abstract excerpt

Full genome sequences of prokaryotic organisms have led to reconstruction of genome-scale metabolic networks and in silico computation of their integrated functions. The first genome-scale metabolic reconstruction for a eukaryotic cell, Saccharomyces cerevisiae, consisting of 1,175 metabolic reactions and 733 metabolites, has appeared. A constraint-based in silico analysis procedure was used to compute properties...

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PMID: 14578455
DOI: 10.1073/pnas.2235812100
PMCID: PMC263729

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