Article
Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.
The American journal of pathology - 1 Nov 2003
Sampath Janardhan, Long Pandy R, Shepard Robert L, Xia Xiaoling, Devanarayan Viswanath, Sandusky George E, Perry William L, Dantzig Anne H, Williamson Mark, Rolfe Mark, Moore Robert E
Abstract excerpt
Our effort to identify novel drug-resistant genes in cyclophosphamide-resistant EMT6 mouse mammary tumors led us to the identification of SPF45. Simultaneously, other groups identified SPF45 as a component of the spliceosome that is involved in alternative splicing. We isolated the human homologue and examined the normal human tissue expression, tumor expression, and the phenotype caused by overexpression of...
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