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Article

Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis.

Cell death and differentiation - 1 Feb 2004

Lopez-Hernandez F J, Ortiz M A, Bayon Y, Piedrafita F J

Abstract excerpt

Certain retinoid-related molecules (RRMs) with agonist or antagonist activities have been described to induce apoptosis in a variety of cancer cell lines and show promise for the treatment of cancer. Similar to other chemotherapeutic drugs, these retinoid analogs have been suggested to induce apoptosis through the intrinsic pathway, which requires the release of cytochrome c from the mitochondria for the...

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PMID: 14576769
DOI: 10.1038/sj.cdd.4401329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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