Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors.

doi:10.1093/emboj/18.2.330

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Article

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors.

The EMBO journal - 15 Jan 1999

Ekert P G, Silke J, Vaux D L

Abstract excerpt

To study the role of various caspases during apoptosis, we have designed a series of caspase inhibitors based on the cowpox virus cytokine response modifier A (crmA) protein. Wild-type crmA inhibits caspases 1 and 8 and thereby protects cells from apoptosis triggered by ligation of CD95 or tumour...

Topics

Amino Acid Sequence
Animals
Apoptosis
Base Sequence
Caspase Inhibitors
Caspases
Cell Division
Cell Line
Cell Survival
Cysteine Proteinase Inhibitors
DNA Primers
Dexamethasone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Gamma Rays

Gene Expression

Genetic Variation

Humans

Mice

Source

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Identifiers

PMID: 9889190
DOI: 10.1093/emboj/18.2.330
PMCID: PMC1171128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9889190-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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