Article
Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis.
The Journal of infectious diseases - 1 Oct 2004
Chakhaiyar Prachee, Nagalakshmi Yellajosyula, Aruna Bandi, Murthy Kolluri J R, Katoch Vishwa M, Hasnain Seyed E
Abstract excerpt
The function of the PE/PPE families of proteins, which represent approximately 10% of the coding capacity of the Mycobacterium tuberculosis genome, has remained relatively unknown. We earlier described a PPE family member, Rv2430c, as an immunodominant antigen. We now report another PPE family gene, Rv2608, a member of the major polymorphic tandem repeat subfamily, for its ability to elicit a high humoral and a...
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