Article
A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events.
PLoS computational biology - 1 Nov 2015
Li Jia, Poursat Marie-Anne, Drubay Damien, Motz Arnaud, Saci Zohra, Morillon Antonin, Michiels Stefan, Gautheret Daniel
Abstract excerpt
We address here the issue of prioritizing non-coding mutations in the tumoral genome. To this aim, we created two independent computational models. The first (germline) model estimates purifying selection based on population SNP data. The second (somatic) model estimates tumor mutation density based on whole genome tumor sequencing. We show that each model reflects a different set of constraints acting either on...
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