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Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations

7 Mar 2019

Abstract excerpt

Individual instances of cancer are primarily a result of a combination of a small number of genetic mutations (hits). Knowing the number of such mutations is a prerequisite for identifying specific combinations of carcinogenic mutations and understanding the etiology of cancer. We present a mathematical model for estimating the number of hits based on the distribution of somatic mutations. The model is...

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PMID: 30845172
DOI: 10.1371/journal.pcbi.1006881

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