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Article

Functional defect in regulatory T cells in myasthenia gravis

1 Dec 2012

Abstract excerpt

Forkhead box P3 (FOXP3) is a transcription factor necessary for the function of regulatory T cells (T(reg) cells). T(reg) cells maintain immune homeostasis and self-tolerance and play an important role in the prevention of autoimmune disease. Here, we discuss the role of T(reg) cells in the pathogenesis of myasthenia gravis (MG) and review evidence indicating that a significant defect in T(reg) cell in vitro...

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PMID: 23252899
DOI: 10.1111/j.1749-6632.2012.06840.x

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