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Article

Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y.

Psychopharmacology - 1 Apr 2001

Sudakov S K, Medvedeva O F, Rusakova I V, Terebilina N N, Goldberg S R

Abstract excerpt

RATIONALE: Regulatory neuropeptide systems appear to modulate anxiety and emotionality, since anxiety in rats can be increased by intracerebroventricular (ICV) administration of diazepam-binding-inhibitor fragment (DBI) and decreased by ICV administration of neuropeptide Y (NPY) or substance P (SP). OBJECTIVE: Involvement of these three neuropeptides in genetic predisposition to anxiety was studied in two inbred...

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Source

Identifiers

PMID: 11349384
DOI: 10.1007/s002130000651

Genes

NPY
DBI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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