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Article

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Jin F, Wienecke R, Xiao G H, Maize J C, DeClue J E, Yeung R S

Abstract excerpt

The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase activating protein (GAP) designated tuberin. Studies of the Eker rat model of hereditary cancer strongly support the role of Tsc2 as a tumor suppressor gene. In this study, the biological activity of tuberin was assessed by expressing the wild-type Tsc2 gene in...

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Identifiers

PMID: 8799170
DOI: 10.1073/pnas.93.17.9154
PMCID: PMC38611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.PMID 8799170Read ↗

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Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.Semantic proximity Read ↗

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Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2Semantic proximity Read ↗

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.Semantic proximity Read ↗

Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.Semantic proximity Read ↗

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITYSemantic proximity Read ↗

Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.Semantic proximity Read ↗

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Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).Semantic proximity Read ↗

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