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Article

Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminase.

The Journal of allergy and clinical immunology - 1 Oct 2003

Kasahara Yukiko, Kaneko Hideo, Fukao Toshiyuki, Terada Tomoyoshi, Asano Tsutomu, Kasahara Kimiko, Kondo Naomi

Abstract excerpt

BACKGROUND: Hyper-IgM immunodeficiency is an immunologic disorder characterized by normal or increased serum IgM levels and reduced serum IgG and IgA levels caused by the disruption of Ig class switching in B cells. The gene encoding activation-induced cytidine deaminase (AID) is responsible for the autosomal recessive form of hyper-IgM syndrome. OBJECTIVE: To investigate the relationship between the AID gene...

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Identifiers

PMID: 14564357
DOI: 10.1016/s0091-6749(03)01860-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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