Article
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Cancer research - 1 Oct 2003
Kim Duk-Hwan, Kim Jin Seuk, Park Jung-Ho, Lee Suk Kyoo, Ji Yong-Ick, Kwon Young Mi, Shim Young Mog, Han Joungho, Park Joobae
Abstract excerpt
Recently, several groups have reported that Ras association domain family 1 (RASSF1A) interacts with Ras and mediates Ras-dependent apoptosis. However, the mechanism by which RASSF1A plays a role as a tumor suppressor in human cancer is unclear. In this study, we investigated the relationship between the RASSF1A methylation and K-ras mutation and their effects on patient's survival in 242 primary non-small cell...
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