Article
FOXO4-knockdown suppresses oxidative stress-induced apoptosis of early pro-angiogenic cells and augments their neovascularization capacities in ischemic limbs.
PloS one - 1 Jan 2014
Nakayoshi Takaharu, Sasaki Ken-Ichiro, Kajimoto Hidemi, Koiwaya Hiroshi, Ohtsuka Masanori, Ueno Takafumi, Chibana Hidetoshi, Itaya Naoki, Sasaki Masahiro, Yokoyama Shinji, Fukumoto Yoshihiro, Imaizumi Tsutomu
Abstract excerpt
The effects of therapeutic angiogenesis by intramuscular injection of early pro-angiogenic cells (EPCs) to ischemic limbs are unsatisfactory. Oxidative stress in the ischemic limbs may accelerate apoptosis of injected EPCs, leading to less neovascularization. Forkhead transcription factor 4 (FOXO4) was reported to play a pivotal role in apoptosis signaling of EPCs in response to oxidative stress. Accordingly, we...
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