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Article

Characterization of the Human FLICE‐Inhibitory Protein Locus and Comparison of the Anti‐Apoptotic Activity of Four Different FLIP Isoforms

1 Jul 2001

Abstract excerpt

Death receptor-mediated apoptosis is involved in the regulation of immune responses and in the maintenance of immunological tolerance. FLICE-inhibitory proteins (FLIPs) are important modulators of death receptor-mediated apoptosis. To date, the FLIP family encompasses multiple members, of which some are reported to be antiapoptotic and others pro-apoptotic. This led us to investigate the activity of several FLIP...

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PMID: 11439165
DOI: 10.1046/j.1365-3083.2001.00941.x

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