Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.

Molecular biology of the cell - 1 Dec 2014

Niles Brad J, Powers Ted

Abstract excerpt

The evolutionarily conserved mTOR complex 2 (mTORC2) signaling pathway is an important regulator of actin cytoskeletal architecture and, as such, is a candidate target for preventing cancer cell motility and invasion. Remarkably, the precise mechanism(s) by which mTORC2 regulates the actin cytoskeleton have remained elusive. Here we show that in budding yeast, TORC2 and its downstream kinase Ypk1 regulate actin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Glycogen Synthase Kinase 3
Share to Mechanistic Target of Rapamycin Complex 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Multiprotein Complexes

Share to Protein Kinase C

Share to Sphingolipids

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25253719
DOI: 10.1091/mbc.E14-06-1122
PMCID: PMC4244204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.PMID 25253719Read ↗

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.Semantic proximity Read ↗

Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.Semantic proximity Read ↗

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Semantic proximity Read ↗

Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p.Semantic proximity Read ↗

TOR2 is required for organization of the actin cytoskeleton in yeast.Semantic proximity Read ↗

Who does TORC2 talk to?Semantic proximity Read ↗

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.Semantic proximity Read ↗

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.Semantic proximity Read ↗

Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae.Semantic proximity Read ↗

Growth Control Under Stress: mTOR Regulation through the REDD1-TSC PathwaySemantic proximity Read ↗

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.Semantic proximity Read ↗

Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.