Article
Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression.
Developmental cell - 1 Oct 2003
Edinger Aimee L, Cinalli Ryan M, Thompson Craig B
Abstract excerpt
Growth factor withdrawal results in the endocytosis and degradation of transporter proteins for glucose and amino acids. Here, we show that this process is under the active control of the small GTPase Rab7. In the presence of growth factor, Rab7 inhibition had no effect on nutrient transporter expression. In growth factor-deprived cells, however, blocking Rab7 function prevented the clearance of glucose and amino...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.