Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZIC1 Is a Putative Tumor Suppressor in Thyroid Cancer by Modulating Major Signaling Pathways and Transcription Factor FOXO3a

31 Mar 2014

Abstract excerpt

CONTEXT: ZIC1 has been reported to be overexpressed and plays an oncogenic role in some brain tumors, whereas it is inactivated by promoter hypermethylation and acts as a tumor suppressor in gastric and colorectal cancers. However, until now, its biological role in thyroid cancer remains totally unknown. OBJECTIVES: The aim of this study is to explore the biological functions and related molecular mechanism of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to FOXO transcription factor regulation
Share to Thyroid Cancer Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24684457
DOI: 10.1210/jc.2013-3729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZIC1 Is a Putative Tumor Suppressor in Thyroid Cancer by Modulating Major Signaling Pathways and Transcription Factor FOXO3aPMID 24684457Read ↗

Epigenetic silencing of ZIC4 unveils a potential tumor suppressor role in pediatric choroid plexus carcinomaSemantic proximity Read ↗

Zic Family Member 2 (ZIC2): a Potential Diagnostic and Prognostic Biomarker for Pan-CancerSemantic proximity Read ↗

Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathwaySemantic proximity Read ↗

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migrationSemantic proximity Read ↗

ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancerSemantic proximity Read ↗

Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinomaSemantic proximity Read ↗

LINC01410/miR-3619-5p/FOXM1 Feedback Loop Regulates Papillary Thyroid Carcinoma Cell Proliferation and Apoptosis.Semantic proximity Read ↗

Promoter methylation of WNT inhibitory factor-1 may be associated with the pathogenesis of multiple human tumors.Semantic proximity Read ↗

Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cellsSemantic proximity Read ↗

Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signalingSemantic proximity Read ↗

Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.Semantic proximity Read ↗

FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.