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Article

DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications.

Nature protocols - 1 Jan 2007

Zeglis Brian M, Barton Jacqueline K

Abstract excerpt

This protocol describes the syntheses and applications of two metallointercalators, Rh(bpy)2(chrysi)3+ and Rh(bpy)2(phzi)3+, that target single base mismatches in DNA. The complexes bind mismatched DNA sites specifically and, upon photoactivation, promote strand scission neighboring the mismatch. Owing to their high specificity and sequence context independence, targeting mismatches with these complexes offers an...

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 17406597
DOI: 10.1038/nprot.2007.22
PMCID: PMC2754800

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Source receipt: pubmed, retrieved 7 Sept 2026.

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