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Article

Base modifications in plasmid DNA caused by potassium permanganate.

Archives of biochemistry and biophysics - 1 Oct 1990

Akman S A, Doroshow J H, Dizdaroglu M

Abstract excerpt

KMnO4 is a powerful oxidizing agent which has been used to modify DNA bases. In previous studies, mild KMnO4 treatment has been shown to preferentially modify Thy; Cyt and Gua are modified only under harsher conditions to as yet unidentified products. In the present study, denatured plasmid pCMV beta gal DNA was exposed to 0.015-1.5 mM KMnO4, pH 8.6, at 4 degrees C for 5 min, after which the DNA was hydrolyzed in...

Topics

Adenine
Cytosine
DNA Damage
Escherichia coli
Gas Chromatography-Mass Spectrometry
Guanine
Mutation
Plasmids
Potassium Permanganate
Thymine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2221919
DOI: 10.1016/0003-9861(90)90105-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2221919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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