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Article

Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.

Acta pharmacologica Sinica - 1 Oct 2003

Zhao Wen-Juan, Ma Ying-Hua, Fei Jian, Mei Zhen-Tong, Guo Li-He

Abstract excerpt

AIM: The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. METHODS: Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively. The anticonvulsant effect of ethyl nipecotate was tested by its intraperitoneal...

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PMID: 14531940

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