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Article

Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice.

Cell death & disease - 28 May 2021

Li Xinxiao, Guo Shengnan, Xu Siying, Chen Zhangping, Wang Lei, Ding Jiangwei, Huo Junming, Xiao Lifei, He Zhenquan, Jin Zhe, Wang Feng, Sun Tao

Abstract excerpt

Mutations in the GABRG2 gene encoding the γ-aminobutyric acid (GABA) A receptor gamma 2 subunit are associated with genetic epilepsy with febrile seizures plus, febrile seizures plus, febrile seizures, and other symptoms of epilepsy. However, the mechanisms underlying Gabrg2-mediated febrile seizures are poorly understood. Here, we used the Cre/loxP system to generate conditional knockout (CKO) mice with...

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Identifiers

PMID: 34050134
DOI: 10.1038/s41419-021-03846-x
PMCID: PMC8163876

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