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Article

Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.

Epilepsy research - 1 Dec 2012

Harai Tomomi, Inoue Ran, Fujita Yuko, Tanaka Ayumi, Horio Mao, Hashimoto Kenji, Hongou Kazuhisa, Miyawaki Toshio, Mori Hisashi

Abstract excerpt

The N-methyl-D-aspartate (NMDA)-type glutamate receptor plays a key role in excitatory synaptic transmission. The overactivation of the NMDA receptor has been implicated in the development of epileptic seizures. D-Serine is a coagonist of the NMDA receptor and its biosynthesis is catalyzed by ser...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22742962
DOI: 10.1016/j.eplepsyres.2012.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22742962-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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