Article

Non-detectable levels of 6-thioguanine nucleotides and 6-methylmercaptopurine in a patient treated with azathioprine: a case report

2007-04-01

Abstract excerpt

<h4>Introduction:</h4> Azathioprine (AZA) is a thiopurine prodrug clinically used for immunosuppression in the treatment of auto-immune inflammatory diseases and in regimens of organ transplantations. The pharmacological action of AZA is based on the formation of 6-mercaptopurine (6-MP), which is metabolised into a variety of active thiopurine-nucleotide metabolites. We report the case of a 55 year old woman (body...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c98e2fd-fcb4-5e77-a8a4-15434df77af2
DOI: 10.1111/j.1365-2125.2007.02886_10.x
PMCID: PMC2203228

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-detectable levels of 6-thioguanine nucleotides and 6-methylmercaptopurine in a patient treated with azathioprine: a case reportDOI 10.1111/j.1365-2125.2007.02886_10.xRead

<i>ITPA</i> genotyping test does not improve detection of Crohn’s disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression: Table 1Semantic proximity Read

Pharmacological monitoring of azathioprine therapy.Semantic proximity Read

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tangoSemantic proximity Read

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read

Effective long-term solution to therapeutic remission in Inflammatory Bowel Disease: Role of Azathioprine.Semantic proximity Read

6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine.Semantic proximity Read

Thiopurines, DNA damage, DNA repair and therapy-related cancerSemantic proximity Read

Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase.Semantic proximity Read

Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.Semantic proximity Read

Analytic aspects of monitoring therapy with thiopurine medications.Semantic proximity Read

[Pharmacological and pharmacogenetic study of two immunomodulators: azathioprine and 6-mercaptopurine. Strategies for preventing complications].Semantic proximity Read

Azathioprine and 6‐mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel diseaseSemantic proximity Read