Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure.

The American journal of medicine - 15 May 2004

Cicoira Mariantonietta, Rossi Andrea, Bonapace Stefano, Zanolla Luisa, Perrot Andreas, Francis Darrel P, Golia Giorgio, Franceschini Lorenzo, Osterziel Karl J, Zardini Piero

Abstract excerpt

BACKGROUND: Angiotensin-converting enzyme (ACE) is involved in the pathophysiology of chronic heart failure, and its activity is determined in part by a polymorphism of the ACE gene. We hypothesized that the benefits of spironolactone, which inhibits downstream elements of ACE-mediated abnormalities, may depend on ACE genotype. METHODS: We randomly assigned 93 chronic heart failure patients to treatment with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diuretics
Share to Echocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Multivariate Analysis

Share to Peptidyl-Dipeptidase A

Share to Polymorphism, Genetic

Share to Regression Analysis

Share to Stroke Volume

Source

Identifiers

PMID: 15121491
DOI: 10.1016/j.amjmed.2003.12.033

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure.PMID 15121491Read ↗

Angiotensin-converting enzyme genotype modulates pulmonary function and exercise capacity in treated patients with congestive stable heart failure.Semantic proximity Read ↗

Impact of renin-angiotensin-aldosterone system gene polymorphisms on left ventricular dysfunction in coronary artery disease patients.Semantic proximity Read ↗

Genetic polymorphism, medical therapy and sequential cardiac function in patients with heart failure.Semantic proximity Read ↗

Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure.Semantic proximity Read ↗

Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure.Semantic proximity Read ↗

Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study.Semantic proximity Read ↗

Effect of the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene on Response to Angiotensin-Converting Enzyme Inhibitors in Patients with Heart FailureSemantic proximity Read ↗

ACE-Inhibition Benefit on Lung Function in Heart Failure is Modulated by ACE Insertion/Deletion Polymorphism.Semantic proximity Read ↗

Beta-adrenergic receptor blockade and the angiotensin-converting enzyme deletion polymorphism in patients with chronic heart failure.Semantic proximity Read ↗

Deletion-type allele of the angiotensin-converting enzyme gene is associated with progressive ventricular dilation after anterior myocardial infarction. Captopril and Thrombolysis Study Investigators.Semantic proximity Read ↗

NR3C2 genotype is associated with response to spironolactone in diastolic heart failure patients from the Aldo-DHF trial.Semantic proximity Read ↗

Lack of association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and idiopathic dilated cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.