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Article

Immortalization of human articular chondrocytes and induction of their phenotype.

Chinese medical journal - 1 Sept 2003

He Qingyi, Li Qihong, Yang Liu, Xu Jianzhong

Abstract excerpt

OBJECTIVE: To immortalize human articular chondrocytes (HACs) using gene transfection and to maintain stable phenotype of transformed HACs after induction. METHODS: HACs were transfected with the retroviral vector pLXSN encoding human papillomavirus 16E7 (HPV16E7), and the transformed clones were sorted and proliferated. Karyotype analysis, clone forming tests and nude mice tumor forming tests were applied to...

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PMID: 14527364

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