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Article

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family.

Nature reviews. Genetics - 1 Oct 2003

Waite Kristin A, Eng Charis

Abstract excerpt

Transforming growth factor-beta (TGF-beta) regulates many cellular processes through complex signal-transduction pathways that have crucial roles in normal development. Disruption of these pathways can lead to a range of diseases, including cancer. Mutations in the genes that encode members of the TGF-beta pathway are involved in vascular diseases as well as gastrointestinal neoplasia. More recently, they have...

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Source

Identifiers

PMID: 14526373
DOI: 10.1038/nrg1178

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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