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Article

Distal limb malformations: underlying mechanisms and clinical associations.

Clinical genetics - 1 Sept 2001

Sifakis S, Basel D, Ianakiev P, Kilpatrick M, Tsipouras P

Abstract excerpt

Congenital malformations of the extremities are conspicuous and have been described through the ages. Over the past decade, a wealth of knowledge has been generated regarding the genetic regulation of limb development and the underlying molecular mechanisms. Recent studies have identified several of the signaling molecules, growth factors, and transcriptional regulators involved in the initiation and maintenance...

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PMID: 11595015
DOI: 10.1034/j.1399-0004.2001.600301.x

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