Article
Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.
Experimental cell research - 15 Feb 2010
Cholay Michael, Reverdy Céline, Benarous Richard, Colland Frédéric, Daviet Laurent
Abstract excerpt
The SYK non-receptor tyrosine kinase is a key effector of immune receptors signaling in hematopoietic cells. Here, we identified and characterized a novel interaction between SYK and the ubiquitin-specific protease 25 (USP25). We report that the second SH2 domain of SYK physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation. Moreover, we showed that SYK...
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