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Article

Onset of dementia is associated with age at menopause in women with Down's syndrome.

Annals of neurology - 1 Oct 2003

Schupf Nicole, Pang Deborah, Patel Bindu N, Silverman Wayne, Schubert Romaine, Lai Florence, Kline Jennie K, Stern Yaakov, Ferin Michel, Tycko Benjamin, Mayeux Richard

Abstract excerpt

Women with Down's syndrome experience early onset of both menopause and Alzheimer's disease. This timing provides an opportunity to examine the influence of endogenous estrogen deficiency, indicated by age at menopause, on risk of Alzheimer's disease. A community-based sample of 163 postmenopausa...

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Identifiers

PMID: 14520653
DOI: 10.1002/ana.10677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14520653-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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