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Article

Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery.

PloS one - 1 Jan 2017

Mosconi Lisa, Berti Valentina, Quinn Crystal, McHugh Pauline, Petrongolo Gabriella, Osorio Ricardo S, Connaughty Christopher, Pupi Alberto, Vallabhajosula Shankar, Isaacson Richard S, de Leon Mony J, Swerdlow Russell H, Brinton Roberta Diaz

Abstract excerpt

After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism...

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Identifiers

PMID: 29016679
DOI: 10.1371/journal.pone.0185926
PMCID: PMC5634623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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