Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and loss of the insertion allele in aldosterone-producing adenoma.

Article

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and loss of the insertion allele in aldosterone-producing adenoma.

Journal of human hypertension - 1 Dec 1996

Tunny T J, Xu L, Richardson K A, Stowasser M, Gartside M, Gordon R D

Abstract excerpt

The genetic mechanisms responsible for the formation of adrenocortical adenomas which autonomously produce aldosterone are largely unknown. The adrenal renin-angiotensin system has been implicated in the pathophysiology of these tumours. Angiotensin-converting enzyme (ACE) catalyses the generatio...

Topics

Adenoma
Adrenal Gland Neoplasms
Alleles
Gene Deletion
Humans
Peptidyl-Dipeptidase A
Polymorphism, Genetic
Sequence Analysis, DNA

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.