Article
Expression of potassium channel isoforms mRNA in normal human adrenals and aldosterone-secreting adenomas.
Journal of endocrinological investigation - 1 Feb 2006
Sarzani R, Pietrucci F, Francioni M, Salvi F, Letizia C, D'Erasmo E, Dessì Fulgheri P, Rappelli A
Abstract excerpt
Increased aldosterone secretion has been found in a mouse lacking the KCNE1 gene which codes for a regulatory protein of the KCNQ1 gene product, forming the channel for the outward rectifying delayed K+ current. Abnormalities in proteins regulating the K+ fluxes across membranes may be responsible for aldosterone-secreting adenomas (aldosteronomas) also because K+ channels are involved in cell growth. Normal and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.