Article
Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation.
FEBS letters - 7 Dec 1992
Voigt C G, Maurer-Fogy I, Adolf G R
Abstract excerpt
Natural human tumor necrosis factor beta (TNF-beta) purified from supernatants of a human B-lymphoblastoid cell line was found to be heterogeneous in molecular mass, with seven components resolved by gel electrophoresis. All components are N-glycosylated at Asn62; N-glycosylation does not contribute to heterogeneity. In addition, part of the molecules are O-glycosylated at Thr7; O-glycosylation is heterogeneous...
Topics
- Alleles
- Amino Acid Sequence
- Asparagine
- B-Lymphocytes
- Genetic Variation
- Glycosylation
- Humans
- Lymphotoxin-alpha
- Molecular Sequence Data
- Neuraminic Acids
- Protein Processing, Post-Translational