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Article

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo.

Oncotarget - 27 Sept 2016

Wegwitz Florian, Lenfert Eva, Gerstel Daniela, von Ehrenstein Lena, Einhoff Julia, Schmidt Geske, Logsdon Matthew, Brandner Johanna, Tiegs Gisa, Beauchemin Nicole, Wagener Christoph, Deppert Wolfgang, Horst Andrea Kristina

Abstract excerpt

We analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice). We demonstrate that silencing of CEACAM1 in WAP-T tumor-derived G-2 cells induces epithelial-mesenchymal plasticity (EMP), as evidenced by typical changes of gene expression, morphology and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27572314
DOI: 10.18632/oncotarget.11650
PMCID: PMC5325399

Genes

CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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