Article
Experimental assignment of the structure of the transition state for the association of barnase and barstar.
Journal of molecular biology - 20 Apr 2001
Frisch C, Fersht A R, Schreiber G
Abstract excerpt
Association of a protein complex follows a two step reaction mechanism, with the first step being the formation of an encounter complex which evolves into the final complex. Here we present new experimental data for the association of the bacterial ribonuclease barnase and its polypeptide inhibitor barstar which shed light on the thermodynamics and structure of the transition state and preceding encounter complex...
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