Article
The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose.
Pharmacogenetics - 1 Oct 2003
Dally Heike, Edler Lutz, Jäger Birgit, Schmezer Peter, Spiegelhalder Bertold, Dienemann Hendrik, Drings Peter, Schulz Volker, Kayser Klaus, Bartsch Helmut, Risch Angela
Abstract excerpt
CYP3A isozymes are involved in tobacco carcinogen- and steroid-metabolism, and are expressed in human lung tissue showing interindividual variation in expression and activity. The CYP3A4*1B allele has been associated with a two-fold higher promoter activity and with high-grade prostate cancers. The very frequent intron 3 polymorphism in the CYP3A5 gene (CYP3A5*3) results in decreased CYP3A5 protein levels. A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.