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Article

Respiratory survival mechanisms in acetylcholinesterase knockout mouse.

The European journal of neuroscience - 1 Sept 2003

Chatonnet Fabrice, Boudinot Eliane, Chatonnet Arnaud, Taysse Laurent, Daulon Sébastien, Champagnat Jean, Foutz Arthur S

Abstract excerpt

Cholinergic neurotransmission ensures muscle contraction and plays a role in the regulation of respiratory pattern in the brainstem. Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood. Respiratory adaptation mechanisms which ensure survival of these mice were examined in vivo by whole body plethysmography and in vitro in the...

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Identifiers

PMID: 14511322
DOI: 10.1046/j.1460-9568.2003.02867.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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