Article
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.
The Journal of biological chemistry - 26 Dec 2003
Chou Fan-Li, Hill Justine M, Hsieh Jyh-Cheng, Pouyssegur Jacques, Brunet Anne, Glading Angela, Uberall Florian, Ramos Joe W, Werner Milton H, Ginsberg Mark H
Abstract excerpt
Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). However, bulk ERK1/2 activation does not correlate with suppression. PEA-15 reverses suppression of integrin activation and binds ERK1/2. Here we report that PEA-15 reversal of integrin suppression depends on its capacity to bind ERK1/2, indicating that ERK1/2 function...
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