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Article

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

The Journal of biological chemistry - 26 Mar 2004

Whitehurst Angelique W, Robinson Fred L, Moore Mary Shannon, Cobb Melanie H

Abstract excerpt

ERK2 nuclear-cytoplasmic distribution is regulated in response to hormones and cellular state without the requirement for karyopherin-mediated nuclear import. One proposed mechanism for the movement of ERK2 into the nucleus is through a direct interaction between ERK2 and nucleoporins present in the nuclear pore complex. Previous reports have attributed regulation of ERK2 localization to proteins that activate or...

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Source

Identifiers

PMID: 14707138
DOI: 10.1074/jbc.M310031200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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